A primer on caspase mechanisms.
Ontology highlight
ABSTRACT:
SUBMITTER: Ramirez MLG
PROVIDER: S-EPMC6043420 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
A primer on caspase mechanisms.
Ramirez Monica L Gonzalez MLG Salvesen Guy S GS
Seminars in cell & developmental biology 20180112
Caspases belong to a diverse clan of proteolytic enzymes known as clan CD with highly disparate functions in cell signaling. The caspase members of this clan are only found in animals, and most of them orchestrate the demise of cells by the highly distinct regulated cell death phenotypes known as apoptosis and pyroptosis. This review looks at the mechanistic distinctions between the activity and activation mechanisms of mammalian caspases compared to other members of clan CD. We also compare and ...[more]
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