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A protonic biotransducer controlling mitochondrial ATP synthesis.

ABSTRACT: In nature, protons (H⁺) play an important role in biological activities such as in mitochondrial ATP synthesis, which is driven by a H⁺ gradient across the inner membrane, or in the activation of acid sensing ion channels in neuron cells. Bioprotonic devices directly interface with the H⁺ concentration (pH) to facilitate engineered interactions with these biochemical processes. Here we develop a H⁺ biotransducer that changes the pH in a mitochondrial matrix by controlling the flow of H⁺ between a conductive polymer of sulfonated polyaniline and solution. We have successfully modulated the rate of ATP synthesis in mitochondria by altering the solution pH. Our H⁺ biotransducer provides a new way to monitor and modulate pH dependent biological functions at the interface between the electronic devices and biological materials.

SUBMITTER: Zhang Z

PROVIDER: S-EPMC6043558 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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A protonic biotransducer controlling mitochondrial ATP synthesis.

Zhang Z Z Kashiwagi H H Kimura S S Kong S S Ohta Y Y Miyake T T

Scientific reports 20180712 1

In nature, protons (H+) play an important role in biological activities such as in mitochondrial ATP synthesis, which is driven by a H+ gradient across the inner membrane, or in the activation of acid sensing ion channels in neuron cells. Bioprotonic devices directly interface with the H+ concentration (pH) to facilitate engineered interactions with these biochemical processes. Here we develop a H+ biotransducer that changes the pH in a mitochondrial m ...[more]

PMID: 30002478

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