Ratiometric nanothermometer in vivo based on triplet sensitized upconversion.

ABSTRACT: Temperature is an essential factor that counts for living systems where complicated vital activities are usually temperature dependent. In vivo temperature mapping based on non-contact optical approach will be beneficial for revealing the physiological phenomena behind with minimized influence to the organism. Herein, a highly thermal-sensitive upconversion system based on triplet-triplet annihilation (TTA) mechanism is pioneered to indicate body temperature variation sensitively over the physiological temperature range. The temperature-insensitive NaYF₄: Nd nanophosphors with NIR emission was incorporated into the temperature-responsive TTA-upconversion system to serve as an internal calibration unit. Consequently, a ratiometric thermometer capable of accurately monitoring the temperature changes in vivo was developed with high thermal sensitivity (~7.1% K^-1) and resolution (~0.1?K).

SUBMITTER: Xu M 

PROVIDER: S-EPMC6043590 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature