Ontology highlight
ABSTRACT:
SUBMITTER: Fuchs ACD
PROVIDER: S-EPMC6043591 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Fuchs Adrian C D ACD Maldoner Lorena L Wojtynek Matthias M Hartmann Marcus D MD Martin Jörg J
Nature communications 20180712 1
While protein ubiquitination was long believed to be a truly eukaryotic feature, recently sequenced genomes revealed complete ubiquitin (Ub) modification operons in archaea. Here, we present the structural and mechanistic characterization of an archaeal Rpn11 deubiquitinase from Caldiarchaeum subterraneum, CsRpn11, and its role in the processing of CsUb precursor and ubiquitinated proteins. CsRpn11 activity is affected by the catalytic metal ion type, small molecule inhibitors, sequence characte ...[more]