Dataset Information

Temporary conductive hearing loss in early life impairs spatial memory of rats in adulthood.

ABSTRACT:

Introduction

It is known that an interruption of acoustic input in early life will result in abnormal development of the auditory system. Here, we further show that this negative impact actually spans beyond the auditory system to the hippocampus, a system critical for spatial memory.

Methods

We induced a temporary conductive hearing loss (TCHL) in P14 rats by perforating the eardrum and allowing it to heal. The Morris water maze and Y-maze tests were deployed to evaluate spatial memory of the rats. Electrophysiological recordings and anatomical analysis were made to evaluate functional and structural changes in the hippocampus following TCHL.

Results

The rats with the TCHL had nearly normal hearing at P42, but had a decreased performance with the Morris water maze and Y-maze tests compared with the control group. A functional deficit in the hippocampus of the rats with the TCHL was found as revealed by the depressed long-term potentiation and the reduced NMDA receptor-mediated postsynaptic current. A structural deficit in the hippocampus of those animals was also found as revealed the abnormal expression of the NMDA receptors, the decreased number of dendritic spines, the reduced postsynaptic density and the reduced level of neurogenesis.

Conclusions

Our study demonstrates that even temporary auditory sensory deprivation in early life of rats results in abnormal development of the hippocampus and consequently impairs spatial memory in adulthood.

SUBMITTER: Zhao H

PROVIDER: S-EPMC6043706 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Publications

Temporary conductive hearing loss in early life impairs spatial memory of rats in adulthood.

Zhao Han H Wang Li L Chen Liang L Zhang Jinsheng J Sun Wei W Salvi Richard J RJ Huang Yi-Na YN Wang Ming M Chen Lin L

Brain and behavior 20180531 7

<h4>Introduction</h4>It is known that an interruption of acoustic input in early life will result in abnormal development of the auditory system. Here, we further show that this negative impact actually spans beyond the auditory system to the hippocampus, a system critical for spatial memory.<h4>Methods</h4>We induced a temporary conductive hearing loss (TCHL) in P14 rats by perforating the eardrum and allowing it to heal. The Morris water maze and Y-maze tests were deployed to evaluate spatial ...[more]

PMID: 29855161

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Dataset Information

Temporary conductive hearing loss in early life impairs spatial memory of rats in adulthood.

Introduction

Methods

Results

Conclusions

Publications

Temporary conductive hearing loss in early life impairs spatial memory of rats in adulthood.

Similar Datasets

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