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Using automated electrode localization to guide stimulation management in DBS.


ABSTRACT: Deep Brain Stimulation requires extensive postoperative testing of stimulation parameters to achieve optimal outcomes. Testing is typically not guided by neuroanatomical information on electrode contact locations. To address this, we present an automated reconstruction of electrode locations relative to the treatment target, the subthalamic nucleus, comparing different targeting methods: atlas-, manual-, or tractography-based subthalamic nucleus segmentation. We found that most electrode contacts chosen to deliver stimulation were closest or second closest to the atlas-based subthalamic nucleus target. We suggest that information on each electrode contact's location, which can be obtained using atlas-based methods, might guide clinicians during postoperative stimulation testing.

SUBMITTER: Petersen MV 

PROVIDER: S-EPMC6043763 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Using automated electrode localization to guide stimulation management in DBS.

Petersen Mikkel V MV   Husch Andreas A   Parsons Christine E CE   Lund Torben E TE   Sunde Niels N   Østergaard Karen K  

Annals of clinical and translational neurology 20180608 7


Deep Brain Stimulation requires extensive postoperative testing of stimulation parameters to achieve optimal outcomes. Testing is typically not guided by neuroanatomical information on electrode contact locations. To address this, we present an automated reconstruction of electrode locations relative to the treatment target, the subthalamic nucleus, comparing different targeting methods: atlas-, manual-, or tractography-based subthalamic nucleus segmentation. We found that most electrode contact  ...[more]

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