Unknown

Dataset Information

0

Serum neurofilament light chain is increased in hereditary spastic paraplegias.

ABSTRACT: Blood biomarkers are still largely missing in hereditary spastic paraplegias (HSPs). We here explored Neurofilament light chain (NfL) as a biomarker in HSP. Serum NfL was assessed in 96 HSP (63 genetically confirmed), 96 healthy control, and 33 ALS subjects by single molecule array (Simoa). Compared to controls, NfL was increased in HSP (P < 0.001), correlating with cross-sectional disease progression (? = 0.28). Levels were lower than in ALS (P < 0.001), allowing to differentiate HSP from ALS (AUC = 0.91). Serum NfL might serve as a biomarker in HSP indicating neuronal damage and, if confirmed longitudinally, disease progression. It might also support differentiating HSP from ALS.

SUBMITTER: Wilke C 

PROVIDER: S-EPMC6043776 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Serum neurofilament light chain is increased in hereditary spastic paraplegias.

Wilke Carlo C   Rattay Tim W TW   Hengel Holger H   Zimmermann Milan M   Brockmann Kathrin K   Schöls Ludger L   Kuhle Jens J   Schüle Rebecca R   Synofzik Matthis M  

Annals of clinical and translational neurology 20180521 7

Blood biomarkers are still largely missing in hereditary spastic paraplegias (HSPs). We here explored Neurofilament light chain (NfL) as a biomarker in HSP. Serum NfL was assessed in 96 HSP (63 genetically confirmed), 96 healthy control, and 33 ALS subjects by single molecule array (Simoa). Compared to controls, NfL was increased in HSP (<i>P</i> < 0.001), correlating with cross-sectional disease progression (<i>ρ</i> = 0.28). Levels were lower than in ALS (<i>P</i> < 0.001), allowing to differe  ...[more]

Similar Datasets

Unknown Lipids in the Physiopathology of Hereditary Spastic Paraplegias.
| S-EPMC7059351 | biostudies-literature
Unknown Impaired mitochondrial dynamics underlie axonal defects in hereditary spastic paraplegias.
| S-EPMC6031053 | biostudies-literature
Unknown Neurofilament Light Chain as a Biomarker of Hereditary Transthyretin-Mediated Amyloidosis.
| S-EPMC7884985 | biostudies-literature
Unknown Clinical spectrum and genetic landscape for hereditary spastic paraplegias in China.
| S-EPMC6035405 | biostudies-literature
Unknown Are Cognitive Changes in Hereditary Spastic Paraplegias Restricted to Complicated Forms?
| S-EPMC6558376 | biostudies-literature
Unknown Cognitive dysfunction in hereditary spastic paraplegias and other motor neuron disorders.
| S-EPMC5619265 | biostudies-literature
Unknown Evoked potentials as biomarkers of hereditary spastic paraplegias: A case-control study.
| S-EPMC8631666 | biostudies-literature
Unknown Serum neurofilament light chain withstands delayed freezing and repeated thawing.
| S-EPMC7672085 | biostudies-literature
Unknown Science in motion: common molecular pathological themes emerge in the hereditary spastic paraplegias.
| S-EPMC1735361 | biostudies-other
Unknown Next Generation Molecular Diagnosis of Hereditary Spastic Paraplegias: An Italian Cross-Sectional Study.
| S-EPMC6289125 | biostudies-literature