Ontology highlight
ABSTRACT:
SUBMITTER: Drobek A
PROVIDER: S-EPMC6043851 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Drobek Ales A Moudra Alena A Mueller Daniel D Huranova Martina M Horkova Veronika V Pribikova Michaela M Ivanek Robert R Oberle Susanne S Zehn Dietmar D McCoy Kathy D KD Draber Peter P Stepanek Ondrej O
The EMBO journal 20180511 14
Virtual memory T cells are foreign antigen-inexperienced T cells that have acquired memory-like phenotype and constitute 10-20% of all peripheral CD8<sup>+</sup> T cells in mice. Their origin, biological roles, and relationship to naïve and foreign antigen-experienced memory T cells are incompletely understood. By analyzing T-cell receptor repertoires and using retrogenic monoclonal T-cell populations, we demonstrate that the virtual memory T-cell formation is a so far unappreciated cell fate de ...[more]