Differentially methylated loci in NAFLD cirrhosis are associated with key signaling pathways.
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ABSTRACT:
SUBMITTER: Gerhard GS
PROVIDER: S-EPMC6044005 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
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Differentially methylated loci in NAFLD cirrhosis are associated with key signaling pathways.
Gerhard Glenn S GS Malenica Ivana I Llaci Lorida L Chu Xin X Petrick Anthony T AT Still Christopher D CD DiStefano Johanna K JK
Clinical epigenetics 20180713 1
Altered DNA methylation events contribute to the pathogenesis and progression of metabolic disorders, including nonalcoholic fatty liver disease (NAFLD). Investigations of global DNA methylation patterns in liver biopsies representing severe NAFLD fibrosis have been limited. We used the HumanMethylation 450K BeadChip to analyze genome-wide methylation in patients with biopsy-proven grade 3/4 NAFLD fibrosis/cirrhosis (N = 14) and age- and sex-matched controls with normal histology (N = 15). We id ...[more]
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