Ontology highlight
ABSTRACT:
SUBMITTER: Woll KA
PROVIDER: S-EPMC6044061 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Woll Kellie A KA Zhou Xiaojuan X Bhanu Natarajan V NV Garcia Benjamin A BA Covarrubias Manuel M Miller Keith W KW Eckenhoff Roderic G RG
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20180305 8
Most general anesthetics enhance GABA type A (GABA<sub>A</sub>) receptor activity at clinically relevant concentrations. Sites of action of volatile anesthetics on the GABA<sub>A</sub> receptor remain unknown, whereas sites of action of many intravenous anesthetics have been identified in GABA<sub>A</sub> receptors by using photolabeling. Here, we used photoactivatable analogs of isoflurane (AziISO) and sevoflurane (AziSEVO) to locate their sites on α<sub>1</sub>β<sub>3</sub>γ<sub>2L</sub> and α ...[more]