Ontology highlight
ABSTRACT:
SUBMITTER: Lee JS
PROVIDER: S-EPMC6044435 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Lee Jacob S JS Tato Cristina M CM Joyce-Shaikh Barbara B Gulen Muhammet F MF Cayatte Corinne C Chen Yi Y Blumenschein Wendy M WM Judo Michael M Ayanoglu Gulesi G McClanahan Terrill K TK Li Xiaoxia X Cua Daniel J DJ
Immunity 20150929 4
Whether interleukin-17A (IL-17A) has pathogenic and/or protective roles in the gut mucosa is controversial and few studies have analyzed specific cell populations for protective functions within the inflamed colonic tissue. Here we have provided evidence for IL-17A-dependent regulation of the tight junction protein occludin during epithelial injury that limits excessive permeability and maintains barrier integrity. Analysis of epithelial cells showed that in the absence of signaling via the IL-1 ...[more]