Ontology highlight
ABSTRACT:
SUBMITTER: Singh A
PROVIDER: S-EPMC6044575 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Singh Amandeep A Saha Sourav Taru ST Perumal Shanen S Kaur Mandeep M Kumar Vipan V
ACS omega 20180130 1
Diverse series of isatin-ferrocene conjugates were synthesized via Cu-promoted azide-alkyne cycloaddition reaction with an aim of probing their antiproliferative structure-activity relationship against MCF-7 (estrogen receptor positive) and MDA-MB-231 (triple negative) cell lines. Among the synthesized conjugates, isatin-ferrocenes proved to be more potent against MCF-7, whereas ferrocenylmethoxy-isatins exhibited activity against MDA-MB-231 cell lines. However, the introduction of chalcone moie ...[more]