Core-Shell Nanoparticles as an Efficient, Sustained, and Triggered Drug-Delivery System.

ABSTRACT: One of the challenges in designing a successful drug-delivery vehicle is the control over drug release. Toward this, a number of multifunctional nanoparticles with multiple triggers and complex chemistries have been developed. To achieve an efficient and maximum therapeutic effect, a trigger dependent drug-delivery system with sustained release is desirable. In this paper, we report the use of a combination of thermoresponsive gold core and polymeric shell nanoparticles that can provide a sustained, triggered release of doxorubicin, making the system more efficient compared to individual nanoparticles. The selection of the system was dependent on the best trigger applicable in biological systems and a component responsive to that trigger. Because of the best tissue penetration depth observ

SUBMITTER: Deshpande S 

PROVIDER: S-EPMC6044672 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature