A new strategy to efficiently cleave and form C-H bonds using proton-coupled electron transfer.
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ABSTRACT:
SUBMITTER: Markle TF
PROVIDER: S-EPMC6044737 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
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A new strategy to efficiently cleave and form C-H bonds using proton-coupled electron transfer.
Markle Todd F TF Darcy Julia W JW Mayer James M JM
Science advances 20180713 7
Oxidative activation and reductive formation of C-H bonds are crucial in many chemical, industrial, and biological processes. Reported here is a new strategy for these transformations, using a form of proton-coupled electron transfer (PCET): intermolecular electron transfer coupled to intramolecular proton transfer with an appropriately placed cofactor. In a fluorenyl-benzoate, the positioned carboxylate facilitates rapid cleavage of a benzylic C-H bond upon reaction with even weak 1<i>e</i><sup ...[more]
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