One-Pot Synthesis of Carbon Nanodots in an Organic Medium with Aggregation-Induced Emission Enhancement (AIEE): A Rationale for "Enzyme-Free" Detection of Cholesterol.

ABSTRACT: Addressing the limitations associated with the detection of cholesterol, we present a one-pot synthesis of a carbon nanodot (CD) in an organic medium (CD_org) from a novel bile acid hydrazone-based organogel. Interestingly, CD_org possesses the aggregation-induced emission enhancement (AIEE) phenomenon, which rationally aids in the "enzyme-free" detection of cholesterol through a fluorescence turn-on mechanism. On dilution of the THF/water mixture of CD_org with its poor solvent (water), a 9.8-fold enhancement in its photoluminescence (PL) emission is witnessed. Such an enhancement in PL emission is credited to the occurrence of molecular restrictions due to the formation of nanoaggregates of CD_org, thereby initiating a radiative pathway for exciton

SUBMITTER: Gogoi N 

PROVIDER: S-EPMC6044871 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature