Novel Low-Toxic Derivative of Celastrol Maintains Protective Effect against Acute Renal Injury.
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ABSTRACT:
SUBMITTER: Hu X
PROVIDER: S-EPMC6045326 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
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Novel Low-Toxic Derivative of Celastrol Maintains Protective Effect against Acute Renal Injury.
Hu Xun X Jia Mengdi M Fu Yu Y Zhang Pei P Zhang Zhirong Z Lin Qing Q
ACS omega 20180306 3
This study aimed to novelly design and synthesize an amide derivative as a potential substitute of celastrol (CLT). We constituted the compound celastrol-glucosamine (CLG) by conjugating 1-(2-aminoethoxy)-2-glucosamine to celastrol (CLT) and confirmed its chemical structure by <sup>1</sup>H NMR, <sup>13</sup>C NMR, and LC-MS/MS. Then, the potential efficacy of the CLG was investigated on renal ischemia-reperfusion injury animal models. The results demonstrated that the decorated compound CLG cou ...[more]
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