Ontology highlight
ABSTRACT:
SUBMITTER: Lee EC
PROVIDER: S-EPMC6045419 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Lee Edward C EC Nguyen Chau T H CTH Strounina Ekaterina E Davis-Poynter Nicholas N Ross Benjamin P BP
ACS omega 20180209 2
Mesoporous silica nanoparticles (MSNs) are drug delivery agents that are able to incorporate drugs within their pores. Furthermore, MSNs can be functionalized by attachment of bioactive ligands on their surface to enhance their activity, and nanoparticles modified with glycosaminoglycan (GAG) mimetics inhibit the entry of herpes simplex virus (HSV) into cells. In this study, structure-activity relationships of GAGs attached to MSNs were investigated in relation to HSV-1 and HSV-2, and acyclovir ...[more]