Ontology highlight
ABSTRACT:
SUBMITTER: Wei Y
PROVIDER: S-EPMC6045482 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Wei Yulei Y Pandian Ganesh N GN Yu Zutao Z Zou Tingting T Li Yue Y Darokar Jayant J Hashiya Kaori K Bando Toshikazu T Sugiyama Hiroshi H
ACS omega 20180330 3
Synthetic DNA-binding inhibitors capable of gaining precise control over neurogenesis factors could obviate the current clinical barriers associated with the use of small molecules in regenerative medicine. Here, we report the design and bioefficacy of the synthetic ligand PIP-RBPJ-1, which caused promoter-specific suppression of neurogenesis-associated HES1 and its downstream genes. Furthermore, PIP-RBPJ-1 alone altered the neural-system-associated Notch-signaling factors and remarkably induced ...[more]