Dataset Information

Multi-centre evaluation of recent troponin assays for the diagnosis of NSTEMI.

ABSTRACT:

Objectives

We aimed to compare the use of nine different cardiac troponin (cTn) assays (2 cTnT and 7 cTnI) for the diagnosis of NSTEMI in a single multi-centre population.

Design and methods

One hundred and fifty-eight patients were included (mean age 60 years, SD 17 years), including 23 patients (14%) with NSTEMI.

Results

The analytical comparison highlighted a large heterogeneity of cTn assays, as reflected by percentages of patients with detectable cTn, correlation coefficients, Passing-Bablok comparisons and concordance coefficients. Correlations within cTnI assays were good and correlation within cTnT assays was excellent. Diagnostic performances demonstrated that each cTn assay has specific threshold values. Furthermore, some assays (HS-cTnI and T, cTnI-Pathfast and cTnI-Centaur) indicated high sensitivity and negative predictive value using the limit of detection (LoD) diagnostic strategy. For the latter assays, a significant increase in specificity was found when using the 99th percentile or the H0-H3 strategies, in comparison to the LoD strategy. When applying the European Society of Cardiology H0-H3 algorithm, comparable diagnostic performances were obtained.

Conclusion

All 9 cTn assays indicated overall good diagnostic performances for the diagnosis of NSTEMI in emergency departments when the recommended algorithm based on the variation of cTn value between two measurements at admission and 3?h later was used.

SUBMITTER: Chenevier-Gobeaux C

PROVIDER: S-EPMC6045566 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Publications

Multi-centre evaluation of recent troponin assays for the diagnosis of NSTEMI.

Chenevier-Gobeaux Camille C Deweerdt Louis L Cantero Anne-Valérie AV Renaud Bertrand B Desmaizières Bruno B Charpentier Sandrine S Leroy Aline A Adelaïde Emmanuelle E Collin-Chavagnac Delphine D Bonnefoy-Cudraz Eric E Estepa Laurence L Chekroune Akli A Basco Sylvie S Andrieu Stéphane S Bourgeois Stéphane S Costa Marie-Agnès MA Vallejo Christine C Robert Tiphaine T Ouahabi Siham S Baudin Bruno B Beneteau-Burnat Benedicte B Gorce-Dupuy Anne-Marie AM Ray Patrick P Gast Claire C Dehoux Monique M Lefèvre Guillaume G

Practical laboratory medicine 20180226

<h4>Objectives</h4>We aimed to compare the use of nine different cardiac troponin (cTn) assays (2 cTnT and 7 cTnI) for the diagnosis of NSTEMI in a single multi-centre population.<h4>Design and methods</h4>One hundred and fifty-eight patients were included (mean age 60 years, SD 17 years), including 23 patients (14%) with NSTEMI.<h4>Results</h4>The analytical comparison highlighted a large heterogeneity of cTn assays, as reflected by percentages of patients with detectable cTn, correlation coeff ...[more]

PMID: 30014015

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Dataset Information

Multi-centre evaluation of recent troponin assays for the diagnosis of NSTEMI.

Objectives

Design and methods

Results

Conclusion

Publications

Multi-centre evaluation of recent troponin assays for the diagnosis of NSTEMI.

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