Ontology highlight
ABSTRACT:
SUBMITTER: Gril B
PROVIDER: S-EPMC6045677 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Nature communications 20180713 1
Brain metastases are devastating complications of cancer. The blood-brain barrier (BBB), which protects the normal brain, morphs into an inadequately characterized blood-tumor barrier (BTB) when brain metastases form, and is surrounded by a neuroinflammatory response. These structures contribute to poor therapeutic efficacy by limiting drug uptake. Here, we report that experimental breast cancer brain metastases of low- and high permeability to a dextran dye exhibit distinct microenvironmental g ...[more]