Ontology highlight
ABSTRACT:
SUBMITTER: Lim CH
PROVIDER: S-EPMC6046383 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Lim Chun Hwee CH Adav Sunil S SS Sze Siu Kwan SK Choong Yeu Khai YK Saravanan Rathi R Schmidtchen Artur A
Frontiers in immunology 20180709
Neutrophil extracellular traps (NETs) consist of a decondensed DNA scaffold decorated with neutrophil-derived proteins. The proteome of NETs, or "NETome," has been largely elucidated <i>in vitro</i>. However, components such as plasma and extracellular matrix proteins may affect the NETome under physiological conditions. Here, using a reductionistic approach, we explored the effects of two proteases active during injury and wounding, human thrombin and plasmin, on the NETome. Using high-resoluti ...[more]