Ontology highlight
ABSTRACT:
SUBMITTER: Lee JH
PROVIDER: S-EPMC6046605 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Lee Ji-Hye JH Park Beom Seok BS Han Kang R KR Biering Scott B SB Kim Soo J SJ Choi Jayoung J Seok Jong H JH Alam Intekhab I Chung Mi S MS Kim Ho M HM Hwang Seungmin S Kim Kyung H KH
Frontiers in microbiology 20180703
Norovirus (NoV) is a leading cause of epidemic acute non-bacterial gastroenteritis, and replicates through virion protein genome-linked (VPg)-primed or <i>de novo</i> RNA synthesis by RNA-dependent RNA polymerase (RdRp). VPg is a multifunctional protein that plays crucial roles in viral protein translation and genome replication. However, the interaction between the RdRp and this multifunctional VPg in NoV replication has been unknown. In this study, VPg derived from murine NoV (MNV) was found t ...[more]