Ontology highlight
ABSTRACT:
SUBMITTER: Amaro-Filho SM
PROVIDER: S-EPMC6046686 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Amaro-Filho Sérgio Menezes SM Pereira Chaves Cláudia Bessa CB Felix Shayany Pinto SP Basto Diogo Lisbôa DL de Almeida Liz Maria LM Moreira Miguel Angelo Martins MAM
Papillomavirus research (Amsterdam, Netherlands) 20180409
<h4>Objectives</h4>To compare and describe type-specific characteristics of HPV16, HPV18 and HPV45 in cervical cancer with respect to 3'LCR methylation and disruption of E1/E2.<h4>Methods</h4>The methylation level of 137 cervical cancer samples (70 with HPV16, 37 with HPV18, and 30 with HPV45) of Brazilian patients was analyzed by pyrosequencing. PCR amplifications were performed to characterize E1 and E2 disruption as an episomal surrogate.<h4>Results</h4>The 3'LCR of HPV16 showed a higher meth ...[more]