Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose.
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ABSTRACT:
SUBMITTER: Lomelino CL
PROVIDER: S-EPMC6047028 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose.
Lomelino Carrie L CL Murray Akilah B AB Supuran Claudiu T CT McKenna Robert R
ACS medicinal chemistry letters 20180510 7
Carbonic anhydrase IX (CA IX) expression is important for the regulation of pH in hypoxic tumors and is emerging as a therapeutic target for the treatment of various cancers. Recent studies have demonstrated the selectivity of sucrose, saccharin, and acesulfame potassium for CA IX over other CA isoforms. Reported here is the X-ray crystal structure of CA IX-mimic in complex with sucralose determined to ∼1.5 Å resolution. Furthermore, this structure is compared to the aforementioned sweetener/car ...[more]
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