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High Affinity Neutral Bodipy Fluorophores for Mitochondrial Tracking.

ABSTRACT: We report the first high affinity neutral Bodipy fluorophores for selective imaging of mitochondria with notable sensitivity (?100 nM) and insignificant cytotoxicity even at very high concentration (?100 ?M), when tested against HeLa cells. Further, these fluorophores are chemically robust and require no special conditions for storage.

SUBMITTER: Gayathri T 

PROVIDER: S-EPMC6047038 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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High Affinity Neutral Bodipy Fluorophores for Mitochondrial Tracking.

Gayathri Thumuganti T   Karnewar Santosh S   Kotamraju Srigiridhar S   Singh Surya Prakash SP  

ACS medicinal chemistry letters 20180620 7

We report the first high affinity neutral Bodipy fluorophores for selective imaging of mitochondria with notable sensitivity (∼100 nM) and insignificant cytotoxicity even at very high concentration (∼100 μM), when tested against HeLa cells. Further, these fluorophores are chemically robust and require no special conditions for storage. ...[more]

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