Ontology highlight
ABSTRACT:
SUBMITTER: Fan L
PROVIDER: S-EPMC6047886 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Fan Li L Lu Yichao Y Shen Xiulian X Shao Hong H Suo Lun L Wu Qiang Q
eLife 20180618
Diverse clustered protocadherins are thought to function in neurite morphogenesis and neuronal connectivity in the brain. Here, we report that the protocadherin alpha (<i>Pcdha</i>) gene cluster regulates neuronal migration during cortical development and cytoskeletal dynamics in primary cortical culture through the WAVE (Wiskott-Aldrich syndrome family verprolin homologous protein, also known as Wasf) complex. In addition, overexpression of proline-rich tyrosine kinase 2 (Pyk2, also known as Pt ...[more]