Ontology highlight
ABSTRACT:
SUBMITTER: Kang X
PROVIDER: S-EPMC6048167 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Kang Xue X Kirui Alex A Muszyński Artur A Widanage Malitha C Dickwella MCD Chen Adrian A Azadi Parastoo P Wang Ping P Mentink-Vigier Frederic F Wang Tuo T
Nature communications 20180716 1
The high mortality of invasive fungal infections, and the limited number and inefficacy of antifungals necessitate the development of new agents with novel mechanisms and targets. The fungal cell wall is a promising target as it contains polysaccharides absent in humans, however, its molecular structure remains elusive. Here we report the architecture of the cell walls in the pathogenic fungus Aspergillus fumigatus. Solid-state NMR spectroscopy, assisted by dynamic nuclear polarization and glyco ...[more]