TCM visualizes trajectories and cell populations from single cell data.
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ABSTRACT:
SUBMITTER: Gong W
PROVIDER: S-EPMC6048168 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
TCM visualizes trajectories and cell populations from single cell data.
Gong Wuming W Kwak Il-Youp IY Koyano-Nakagawa Naoko N Pan Wei W Garry Daniel J DJ
Nature communications 20180716 1
Profiling single cell gene expression data over specified time periods are increasingly applied to the study of complex developmental processes. Here, we describe a novel prototype-based dimension reduction method to visualize high throughput temporal expression data for single cell analyses. Our software preserves the global developmental trajectories over a specified time course, and it also identifies subpopulations of cells within each time point demonstrating superior visualization performa ...[more]
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