MicroRNA-199a Inhibits Cellular Autophagy and Downregulates IFN-? Expression by Targeting TBK1 in Mycobacterium bovis Infected Cells.
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ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC6048223 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
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MicroRNA-199a Inhibits Cellular Autophagy and Downregulates IFN-β Expression by Targeting TBK1 in <i>Mycobacterium bovis</i> Infected Cells.
Wang Jie J Hussain Tariq T Yue Ruichao R Liao Yi Y Li Qiang Q Yao Jiao J Song Yinjuan Y Sun Xin X Wang Nan N Xu Lei L Sreevatsan Srinand S Zhao Deming D Zhou Xiangmei X
Frontiers in cellular and infection microbiology 20180710
The mechanism by which microRNAs (miRNAs) modulate innate immunity and autophagy has not been fully elucidated in <i>Mycobacterium bovis</i> (<i>M. bovis</i>) infections. In this study, we identified that miR-199a inhibited key innate immune responses and autophagy in murine macrophages infected with <i>M. bovis</i>. Using <i>ex vivo</i> and <i>in vitro</i> approaches we show that the expression of miR-199a was significantly increased during <i>M. bovis</i> infection. Furthermore, miR-199a suppr ...[more]
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