Ontology highlight
ABSTRACT:
SUBMITTER: Saldi TK
PROVIDER: S-EPMC6048318 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Saldi Tassa K TK Gonzales Patrick P Garrido-Lecca Alfonso A Dostal Vishantie V Roberts Christine M CM Petrucelli Leonard L Link Christopher D CD
Molecular and cellular biology 20180716 15
TDP-1 is the <i>Caenorhabditis elegans</i> ortholog of mammalian TDP-43, which is strongly implicated in the etiology of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We discovered that deletion of the <i>tdp-1</i> gene results in enhanced nuclear RNA interference (RNAi). As nuclear RNAi in <i>C. elegans</i> involves chromatin changes moderated by HPL-2, a homolog of heterochromatin protein 1 (HP1), we investigated the interaction of TDP-1 and HPL-2. We found that TDP-1 ...[more]