Ontology highlight
ABSTRACT:
SUBMITTER: Archer NM
PROVIDER: S-EPMC6048551 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Archer Natasha M NM Petersen Nicole N Clark Martha A MA Buckee Caroline O CO Childs Lauren M LM Duraisingh Manoj T MT
Proceedings of the National Academy of Sciences of the United States of America 20180626 28
Sickle cell trait (AS) confers partial protection against lethal <i>Plasmodium falciparum</i> malaria. Multiple mechanisms for this have been proposed, with a recent focus on aberrant cytoadherence of parasite-infected red blood cells (RBCs). Here we investigate the mechanistic basis of AS protection through detailed temporal mapping. We find that parasites in AS RBCs maintained at low oxygen concentrations stall at a specific stage in the middle of intracellular growth before DNA replication. W ...[more]