Ontology highlight
ABSTRACT:
SUBMITTER: Liu L
PROVIDER: S-EPMC6049086 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Liu Li L Boyd Stefanie S Kavoussi Mehraban M Bulla Lee A LA Winkler Duane D DD
Journal of proteomics & bioinformatics 20180514 4
The Cry1Ab toxin produced by <i>Bacillus thuringiensis</i> binds to a conserved structural motif in the 12<sup>th</sup> ectodomain module (EC12) of BT-R<sub>1</sub>, a cadherin G protein-coupled receptor (GPCR) contained in the membrane of midgut epithelial cells of the tobacco hornworm <i>Manduca sexta</i>. Toxin binding transmits a signal into the cells and turns on a multi-step signal transduction pathway, culminating in cell death. Using chromatographically purified Cry1Ab and EC12 proteins, ...[more]