Ontology highlight
ABSTRACT:
SUBMITTER: Kumar D
PROVIDER: S-EPMC6050074 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Kumar Dhruv D New Jacob J Vishwakarma Vikalp V Joshi Radhika R Enders Jonathan J Lin Fangchen F Dasari Sumana S Gutierrez Wade R WR Leef George G Ponnurangam Sivapriya S Chavan Hemantkumar H Ganaden Lydia L Thornton Mackenzie M MM Dai Hongying H Tawfik Ossama O Straub Jeffrey J Shnayder Yelizaveta Y Kakarala Kiran K Tsue Terance Ted TT Girod Douglas A DA Van Houten Bennett B Anant Shrikant S Krishnamurthy Partha P Thomas Sufi Mary SM
Cancer research 20180516 14
Despite aggressive therapies, head and neck squamous cell carcinoma (HNSCC) is associated with a less than 50% 5-year survival rate. Late-stage HNSCC frequently consists of up to 80% cancer-associated fibroblasts (CAF). We previously reported that CAF-secreted HGF facilitates HNSCC progression; however, very little is known about the role of CAFs in HNSCC metabolism. Here, we demonstrate that CAF-secreted HGF increases extracellular lactate levels in HNSCC via upregulation of glycolysis. CAF-sec ...[more]