Ontology highlight
ABSTRACT:
SUBMITTER: Liu GS
PROVIDER: S-EPMC6050507 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Liu Guan-Sheng GS Gardner George G Adly George G Jiang Min M Cai Wen-Feng WF Lam Chi Keung CK Alogaili Fawzi F Robbins Nathan N Rubinstein Jack J Kranias Evangelia G EG
Journal of cellular and molecular medicine 20180515 8
Heat shock protein 20 (Hsp20) has been shown to be a critical regulator of cardiomyocyte survival upon cardiac stress. In this study, we investigated the functional significance of a novel human Hsp20 mutation (S10F) in peripartum cardiomyopathy. Previous findings showed that cardiac-specific overexpression of this mutant were associated with reduced autophagy, left ventricular dysfunction and early death in male mice. However, this study indicates that females have normal function with no alter ...[more]