Ontology highlight
ABSTRACT:
SUBMITTER: Pascual J
PROVIDER: S-EPMC6050928 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Pascual Julio J Berger Stefan P SP Witzke Oliver O Tedesco Helio H Mulgaonkar Shamkant S Qazi Yasir Y Chadban Steven S Oppenheimer Federico F Sommerer Claudia C Oberbauer Rainer R Watarai Yoshihiko Y Legendre Christophe C Citterio Franco F Henry Mitchell M Srinivas Titte R TR Luo Wen-Lin WL Marti AnaMaria A Bernhardt Peter P Vincenti Flavio F
Journal of the American Society of Nephrology : JASN 20180511 7
<b>Background</b> Everolimus permits reduced calcineurin inhibitor (CNI) exposure, but the efficacy and safety outcomes of this treatment after kidney transplant require confirmation.<b>Methods</b> In a multicenter noninferiority trial, we randomized 2037 <i>de novo</i> kidney transplant recipients to receive, in combination with induction therapy and corticosteroids, everolimus with reduced-exposure CNI (everolimus arm) or mycophenolic acid (MPA) with standard-exposure CNI (MPA arm). The primar ...[more]