Long non-coding RNA GAS5 is induced by interferons and plays an antitumor role in esophageal squamous cell carcinoma.
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SUBMITTER: Huang J
PROVIDER: S-EPMC6051207 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
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Long non-coding RNA GAS5 is induced by interferons and plays an antitumor role in esophageal squamous cell carcinoma.
Huang Jianbing J Li Yuan Y Lu Zhiliang Z Che Yun Y Sun Shouguo S Mao Shuangshuang S Lei Yuanyuan Y Zang Ruochuan R Li Ning N Sun Nan N He Jie J
Cancer medicine 20180509 7
The long non-coding RNA GAS5 has been reported as a tumor suppressor in many cancers. However, its functions and mechanisms remain largely unknown in esophageal squamous cell carcinoma (ESCC). In this study, we found that GAS5 was over-expressed in ESCC tissue compared with that in normal esophageal tissue in a public database. Functional studies showed that GAS5 could inhibit ESCC cell proliferation, migration and invasion in vitro. Further analysis revealed that GAS5 was regulated by interfero ...[more]
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