Ontology highlight
ABSTRACT:
SUBMITTER: Yang TW
PROVIDER: S-EPMC6051654 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Yang Tae-Won TW Moon Jangsup J Kim Tae-Joon TJ Jun Jin-Sun JS Lim Jung-Ah JA Lee Soon-Tae ST Jung Keun-Hwa KH Park Kyung-Il KI Jung Ki-Young KY Chu Kon K Lee Sang Kun SK
PloS one 20180718 7
Levetiracetam (LEV) is effective for focal and generalized epilepsy and is used worldwide because of its relatively few drug interactions and favorable tolerability. However, some psychiatric adverse events (PAEs) have been reported, resulting in drug withdrawal. The pathophysiology of LEV-induced PAE has not yet been elucidated. In this study, we investigated the relationship between PAEs and human leukocyte antigen (HLA) genes. Eleven epilepsy patients, who developed PAEs after the administrat ...[more]