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HLA-A*11:01 is associated with levetiracetam-induced psychiatric adverse events.


ABSTRACT: Levetiracetam (LEV) is effective for focal and generalized epilepsy and is used worldwide because of its relatively few drug interactions and favorable tolerability. However, some psychiatric adverse events (PAEs) have been reported, resulting in drug withdrawal. The pathophysiology of LEV-induced PAE has not yet been elucidated. In this study, we investigated the relationship between PAEs and human leukocyte antigen (HLA) genes. Eleven epilepsy patients, who developed PAEs after the administration of LEV and spontaneously improved after drug withdrawal, were enrolled retrospectively. Genomic DNA from the peripheral blood was extracted, and four-digit allele genotyping of HLA genes was performed. The genotype frequencies of HLA genes were compared to those of 80 patients in which LEV was well tolerated, as well as to 485 individuals from the general Korean population. The frequency of the HLA-A*1101 allele was significantly higher in the LEV-induced PAEs group compared to both the LEV-tolerant group (p = 0.021, OR 4.80, 95% CI 1.30-17.74) and the general Korean population (p = 0.015, OR 4.62, 95% CI 1.38-15.45). This study is the first attempt at investigating the relationship between the HLA system and LEV-induced PAE. The results of this study suggest that the HLA-A*1101 allele could be a risk factor for the development of PAEs.

SUBMITTER: Yang TW 

PROVIDER: S-EPMC6051654 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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HLA-A*11:01 is associated with levetiracetam-induced psychiatric adverse events.

Yang Tae-Won TW   Moon Jangsup J   Kim Tae-Joon TJ   Jun Jin-Sun JS   Lim Jung-Ah JA   Lee Soon-Tae ST   Jung Keun-Hwa KH   Park Kyung-Il KI   Jung Ki-Young KY   Chu Kon K   Lee Sang Kun SK  

PloS one 20180718 7


Levetiracetam (LEV) is effective for focal and generalized epilepsy and is used worldwide because of its relatively few drug interactions and favorable tolerability. However, some psychiatric adverse events (PAEs) have been reported, resulting in drug withdrawal. The pathophysiology of LEV-induced PAE has not yet been elucidated. In this study, we investigated the relationship between PAEs and human leukocyte antigen (HLA) genes. Eleven epilepsy patients, who developed PAEs after the administrat  ...[more]

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