Ontology highlight
ABSTRACT:
SUBMITTER: Ramirez-Sarmiento CA
PROVIDER: S-EPMC6051914 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Ramirez-Sarmiento Cesar A CA Komives Elizabeth A EA
Methods (San Diego, Calif.) 20180406
Hydrogen-deuterium exchange mass spectrometry (HDXMS) has emerged as a powerful approach for revealing folding and allostery in protein-protein interactions. The advent of higher resolution mass spectrometers combined with ion mobility separation and ultra performance liquid chromatographic separations have allowed the complete coverage of large protein sequences and multi-protein complexes. Liquid-handling robots have improved the reproducibility and accurate temperature control of the sample p ...[more]