Cord Blood IL-12 Confers Protection to Clinical Malaria in Early Childhood Life.
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ABSTRACT:
SUBMITTER: Song Y
PROVIDER: S-EPMC6052074 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
Cord Blood IL-12 Confers Protection to Clinical Malaria in Early Childhood Life.
Song Yong Y Aguilar Ruth R Guo Jing J Manaca Maria Nelia MN Nhabomba Augusto A Berthoud Tamara Katherine TK Khoo Siew-Kim SK Wiertsema Selma S Barbosa Arnoldo A Quintó Llorenç L Laing Ingrid A IA Mayor Alfredo A Guinovart Caterina C Alonso Pedro L PL LeSouëf Peter N PN Dobaño Carlota C Zhang Guicheng Brad GB
Scientific reports 20180718 1
Using a well-designed longitudinal cohort, we aimed to identify cytokines that were protective against malaria and to explore how they were influenced by genetic and immunological factors. 349 Mozambican pregnant women and their newborn babies were recruited and followed up for malaria outcomes until 24 months of age. Six Th1 cytokines in cord blood were screened for correlation with malaria incidence, of which IL-12 was selected for further analyses. We genotyped IL-12 polymorphisms in children ...[more]
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