Ontology highlight
ABSTRACT:
SUBMITTER: Zeng J
PROVIDER: S-EPMC6052465 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Zeng Juan J Jiang Manxi M Wu Xinghan X Diao Feiyang F Qiu Danhong D Hou Xiaojing X Wang Haichao H Li Ling L Li Chunling C Ge Juan J Liu Jiayin J Ou Xianghong X Wang Qiang Q
Aging cell 20180529 4
SIRT4 modulates energy homeostasis in multiple cell types and tissues. However, its role in meiotic oocytes remains unknown. Here, we report that mouse oocytes overexpressing SIRT4 are unable to completely progress through meiosis, showing the inadequate mitochondrial redistribution, lowered ATP content, elevated reactive oxygen species (ROS) level, with the severely disrupted spindle/chromosome organization. Moreover, we find that phosphorylation of Ser293-PDHE1α mediates the effects of SIRT4 o ...[more]