Peripheral-blood gene expression profiling studies for coronary artery disease and its severity in Xinjiang population in China.

ABSTRACT:

Background

Alterations in gene expression in peripheral blood cells play a curtail role in the presence and extent of coronary artery disease (CAD), but its severity reflected by gene expression alterations in peripheral blood cells is still unknown in Xinjiang population in China.

Methods

Global gene expression profiling in peripheral blood was used to explore differentially expressed genes in coronary artery stenosis patients. RNA was extracted from peripheral blood of 9 controls without coronary stenosis and 21 cases with angiographically CAD. The extent of CAD severity was categorized angiographically as no CAD, mild CAD (20 to 50% luminal diameter stenosis [LDS]), moderate CAD (50 to 75% LDS) and severe CAD (≥75% LDS). Differentially expressed genes related with CAD sev

SUBMITTER: Liu M 

PROVIDER: S-EPMC6052538 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature