Ontology highlight
ABSTRACT:
SUBMITTER: Lee JJ
PROVIDER: S-EPMC6053448 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Lee Jae-Jin JJ Kim Hwang Suk HS Lee Ji-Sun JS Park Jimin J Shin Sang Chul SC Song Soonwha S Lee Eunsun E Choi Jung-Eun JE Suh Ji-Wan JW Lee Hongsoo H Kim Eunice EunKyeong EE Seo Eun Kyoung EK Shin Dong Hae DH Lee Ho-Young HY Lee Hee-Yoon HY Lee Kong-Joo KJ
Scientific reports 20180719 1
Nm23-H1/NDPK-A is a tumor metastasis suppressor having NDP kinase (NDPK) activity. Nm23-H1 is positively associated with prolonged disease-free survival and good prognosis of cancer patients. Approaches to increasing the cellular levels of Nm23-H1 therefore have significance in the therapy of metastatic cancers. We found a small molecule, (±)-trans-3-(3,4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene, that activates Nm23, hereafter called NMac1. NMac1 directly binds to Nm23-H1 and i ...[more]