Ontology highlight
ABSTRACT:
SUBMITTER: Armstrong JPK
PROVIDER: S-EPMC6054073 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Armstrong James P K JPK Olof Sam N SN Jakimowicz Monika D MD Hollander Anthony P AP Mann Stephen S Davis Sean A SA Miles Mervyn J MJ Patil Avinash J AJ Perriman Adam W AW
Chemical science 20150720 11
We present a new approach for the directed delivery of biomolecular payloads to individual cells with high spatial precision. This was accomplished <i>via</i> active sequestration of proteins, oligonucleotides or molecular dyes into coacervate microdroplets, which were then delivered to specific regions of stem cell membranes using a dynamic holographic assembler, resulting in spontaneous coacervate microdroplet-membrane fusion. The facile preparation, high sequestration efficiency and inherent ...[more]