Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species.
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ABSTRACT:
SUBMITTER: Jha P
PROVIDER: S-EPMC6054463 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species.
Jha Pooja P McDevitt Molly T MT Gupta Rahul R Quiros Pedro M PM Williams Evan G EG Gariani Karim K Sleiman Maroun B MB Diserens Leo L Jochem Adam A Ulbrich Arne A Coon Joshua J JJ Auwerx Johan J Pagliarini David J DJ
Cell systems 20180613 6
The genetics of individual lipid species and their relevance in disease is largely unresolved. We profiled a subset of storage, signaling, membrane, and mitochondrial liver lipids across 385 mice from 47 strains of the BXD mouse population fed chow or high-fat diet and integrated these data with complementary multi-omics datasets. We identified several lipid species and lipid clusters with specific phenotypic and molecular signatures and, in particular, cardiolipin species with signatures of hea ...[more]
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