Impaired spatial memory codes in a mouse model of Rett syndrome.
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ABSTRACT:
SUBMITTER: Kee SE
PROVIDER: S-EPMC6054527 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
Impaired spatial memory codes in a mouse model of Rett syndrome.
Kee Sara E SE Mou Xiang X Zoghbi Huda Y HY Ji Daoyun D
eLife 20180720
The <i>Mecp2<sup>+/-</sup></i> mouse model recapitulates many phenotypes of patients with Rett syndrome (RTT), including learning and memory deficits. It is unknown, however, how the disease state alters memory circuit functions in vivo in RTT mice. Here we recorded from hippocampal place cells, which are thought to encode spatial memories, in freely moving RTT mice and littermate controls. We found that place cells in RTT mice are impaired in their experience-dependent increase of spatial infor ...[more]
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