Ontology highlight
ABSTRACT:
SUBMITTER: Ahmadi S
PROVIDER: S-EPMC6054531 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
eLife 20180713
The severity of intestinal disease associated with Cystic Fibrosis (CF) is variable in the patient population and this variability is partially conferred by the influence of modifier genes. Genome-wide association studies have identified <i>SLC6A14,</i> an electrogenic amino acid transporter, as a genetic modifier of CF-associated meconium ileus. The purpose of the current work was to determine the biological role of <i>Slc6a14,</i> by disrupting its expression in CF mice bearing the major mutat ...[more]