Ontology highlight
ABSTRACT:
SUBMITTER: Zhou W
PROVIDER: S-EPMC6054535 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Zhou Wei W Sun Wei W Yung Mingo M H MMH Dai Sheng S Cai Yihua Y Chen Chi-Wei CW Meng Yunxiao Y Lee Jennifer B JB Braisted John C JC Xu Yinghua Y Southall Noel T NT Shinn Paul P Huang Xuefeng X Song Zhangfa Z Chen Xiulei X Kai Yan Y Cai Xin X Li Zongzhu Z Hao Qiang Q Cheung Annie N Y ANY Ngan Hextan Y S HYS Liu Stephanie S SS Barak Stephanie S Hao Jing J Dai Zhijun Z Tzatsos Alexandros A Peng Weiqun W Pei Huadong H Han Zhiyong Z Chan David W DW Zheng Wei W Zhu Wenge W
Oncogene 20180417 29
Antineoplastic platinum agents are used in first-line treatment of ovarian cancer, but treatment failure frequently results from platinum drug resistance. Emerging observations suggest a role of reactive oxygen species (ROS) in the resistance of cancer drugs including platinum drugs. However, the molecular link between ROS and cellular survival pathway is poorly understood. Using quantitative high-throughput combinational screen (qHTCS) and genomic sequencing, we show that in platinum-resistant ...[more]