Ontology highlight
ABSTRACT:
SUBMITTER: Krzykawska-Serda M
PROVIDER: S-EPMC6054595 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Krzykawska-Serda Martyna M Agha Mahdi S MS Ho Jason Chak-Shing JC Ware Matthew J MJ Law Justin J JJ Newton Jared M JM Nguyen Lam L Curley Steven A SA Corr Stuart J SJ
Translational oncology 20180403 3
Patients with pancreatic ductal adenocarcinomas (PDAC) have one of the poorest survival rates of all cancers. The main reason for this is related to the unique tumor stroma and poor vascularization of PDAC. As a consequence, chemotherapeutic drugs, such as nab-paclitaxel and gemcitabine, cannot efficiently penetrate into the tumor tissue. Non-invasive radiofrequency (RF) mild hyperthermia treatment was proposed as a synergistic therapy to enhance drug uptake into the tumor by increasing tumor va ...[more]