Ontology highlight
ABSTRACT:
SUBMITTER: Lafont F
PROVIDER: S-EPMC6054677 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Lafont Florian F Ayadi Nizar N Charlier Cathy C Weigel Pierre P Nabiev Igor I Benhelli-Mokrani Houda H Fleury Fabrice F
Scientific reports 20180720 1
Therapeutic efficacy against cancer is often based on a variety of DNA lesions, including DNA double-strand breaks (DSBs) which are repaired by homologous recombination and non-homologous end joining (NHEJ) pathways. In the past decade, the functions of the DNA repair proteins have been described as a potential mechanism of resistance in tumor cells. Therefore, the DNA repair proteins have become targets to improve the efficacy of anticancer therapy. Given the central role of DNA-PKcs in NHEJ, t ...[more]