Ontology highlight
ABSTRACT:
SUBMITTER: Murray TA
PROVIDER: S-EPMC6054910 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Murray Thomas A TA Yuan Ying Y Thall Peter F PF Elizondo Joan H JH Hofstetter Wayne L WL
Biometrics 20180122 3
A design is proposed for randomized comparative trials with ordinal outcomes and prognostic subgroups. The design accounts for patient heterogeneity by allowing possibly different comparative conclusions within subgroups. The comparative testing criterion is based on utilities for the levels of the ordinal outcome and a Bayesian probability model. Designs based on two alternative models that include treatment-subgroup interactions are considered, the proportional odds model and a non-proportiona ...[more]